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At least 21 people have been killed after a passenger bus plunged from an overpass near Venice in an “apocalyptic” accident, according to Italian authorities. The vehicle was travelling from Venice to Marghera when the shocking accident took place at the overpass in Mestre on Tuesday evening. “It completely went off the road, it flew off the bridge. It was a bus; it was a highway. We are in mourning,” Venice mayor Luigi Brugnaro told Italy’s national broadcaster RAI. At least four Ukrainians and one German tourist were among the dead, local authorities said. Morris Ceron, general director of the municipality of Venice, told RAI that children were among the victims of the crash and that the bus was believed to have foreigners aboard as it headed towards a campsite. Luca Zaia, president of Italy’s Veneto region, called the bus crash “a tragedy of enormous proportions” and also confirmed that “the victims and injured are of various nationalities, not just Italians.” He said that more than 20 ambulances had been used at the scene and also the Treviso air ambulance. The injured were taken to hospitals in Mestre, Mirano, Padua and Treviso. Read More At least 21 dead after passenger bus plunges off overpass near Venice A bus crash near Italian city of Venice kills at least 21 people, including Ukrainian tourists

By Xinghui Kok SINGAPORE To own a car in Singapore, a buyer must bid for a certificate that

Russia says its air defenses shot down 31 Ukrainian drones in a nighttime attack on border regions

Almost one in 10 middle-aged men and more than a quarter of middle-aged women in the UK are “fit but fat”, researchers have said, as they called for more to be done to help people reduce their weight. Academics said that there are large regional differences over levels of “metabolically healthy obesity”, which could be down to different diets or other lifestyle factors as well as ethnic and genetic differences. People who are “fit but fat” are considered to be obese by their body mass index (BMI) score but have none of the complications associated with obesity including abnormal blood sugar levels; high cholesterol; high blood pressures; type 2 diabetes or other signs of heart disease. The UK has similar levels seen in Sweden, Norway and Germany, experts said. The highest proportion of metabolically healthy obesity is observed in France and other Mediterranean countries such as Italy and Israel, experts told the the Annual Meeting of the European Association for the Study of Diabetes. There will always be people living with obesity who seem to be protected against obesity-related cardiometabolic diseases Prof Mattias Bluher One study shows that 8% of men and 27% of women in the UK aged between 40 and 50 are living with “metabolically healthy obesity”. Asked how many people in the UK are affected, Professor Matthias Bluher, of the University of Leipzig and Helmholtz Centre Munich in Germany, said: “The (UK) is very similar to situation Sweden, Norway and Germany. “There are populations in Micronesia or Asian populations where it is down to 2-5% only. “Some populations may be, despite large amounts of adipose tissue, better protected against comorbidities and Caucasian populations belong to those.” Prof Bluher said that healthy obesity is seen in a number of premenopausal women. It comes as Prof Bluher called for better weight management programmes for people who fit the profile. He pointed to previous work which suggests people who are “healthy obese” have a higher risk of coronary heart disease, cerebrovascular disease and heart failure compared to their in a normal weight range. “There will always be people living with obesity who seem to be protected against obesity-related cardiometabolic diseases,” he told the conference. “The concept that metabolically healthy obesity affected people may not benefit from weight loss strategies has been challenged by recent data. “A timely and personalised treatment of obesity should also be recommended to people living with healthier obesity.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Jonnie Peacock on Strictly Come Dancing representation: ‘It’s important to break people’s perceptions’ What you need to know about depression during menopause – as Carol Vorderman opens up Autumn pests to look out for and how to get rid of them in your home and garden

KYIV Ukraine's navy said on Wednesday that 12 more vessels were ready to enter a Black Sea shipping

The photo, showing the combination of numbers 6 and 4 , has been scrubbed on Chinese social media.

A selloff in global bond markets gathered pace, driving yields to the highest level in more than a

Police in New Delhi have arrested the editor of a news website and one of its administrators after raiding the homes of journalists working for the site, which has been critical of Prime Minister Narendra Modi's Hindu nationalist-led government

Swedish media say the Royal Swedish Academy of Sciences may have announced the winners of this year’s Nobel Prize in chemistry prematurely

The Republican says the vote was "personal", lashing out at his political nemesis, Matt Gaetz.

Three homes were destroyed by a forest fire and a man was injured by a falling tree in the Bega Valley region of southeastern Australia, prompting a government leader to warn that a “horror” wildfire season is approaching

Japanese government bonds fell further on Wednesday, increasing pressure on the central bank to raise its yield-curve cap