List of All Articles with Tag 'n'

'I definitely feel like I can do something entrepreneurial,' Olivia Dunne said

Oliver Anthony was falsely rumored to be joining Jason Aldean and Kid Rock for a tour

Scientists have grown human kidneys in pigs, for the very first time. Researchers at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Wuyi University created human-pig chimeric embryos containing a combination of human and pig cells. When they transferred into 13 surrogate pig mothers, they developed kidneys that contained mostly human cells at a rate of 50 to 60 per cent, giving hope for potential transplants in the future. “Rat organs have been produced in mice, and mouse organs have been produced in rats, but previous attempts to grow human organs in pigs have not succeeded,” said the senior author Liangxue Lai. “Our approach improves the integration of human cells into recipient tissues and allows us to grow human organs in pigs.” The kidneys were not entirely human as they included vasculature and nerves made mostly from pig cells, meaning they could not be used for transplantation in their current form, but it is still a pretty impressive step. And apart from the kidneys, the embryos were dominated by pig cells, with very few human cells in the brain or central nervous system. Making brains using human and pig cells is very controversial for ethical reasons, so there are tight regulations for this kind of research. Meanwhile, pig cells tend to outcompete human cells during development, so previous experiments have created embryos that are almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a gap within the embryo that could be filled by human cells. “We found that if you create a niche in the pig embryo, then the human cells naturally go into these spaces,” said Prof Zhen Dai of Guangzhou Institutes of Biomedicine and Health, another senior author. The scientists said that being able to incubate a fully human kidney inside a pig would be likely to take many years. “We would probably need to engineer the pigs in a much more complex way and that also brings some additional challenges,” said Miguel Esteban, also of the Guangzhou institute and a senior author. A central challenge would be to allow human nerves and vasculature to develop within the target organ without nerve cells developing in the central nervous system that could lead to a humanised brain. “Even theoretically it’s not clear how you’d do that,” said Ilic. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

By Shristi Achar A and Amruta Khandekar (Reuters) -U.S. stock index futures were subdued on Friday as investors awaited a

Paige Spiranac said, 'I am having amazing and loyal supporters, followers, people who tune in every single week'

The Oregon Innocence Project accused the state of Oregon of perpetrating a 'heinous injustice' against Jesse Johnson, who spent 25 years behind bars

KSI said, 'I know Speed’s gonna try and score against me so, I’m gonna concede zero, that is my mission to make Speed score zero'

A Russian missile attack on President Volodymyr Zelenskyy’s hometown in central Ukraine has killed one policeman and injured at least 52 others

As Covid cases spread in 2020, visitors to the University of Arkansas for Medical Sciences were greeted by a colorful sign put up by grateful neighbors outside the university's medical center: "Heroes Work Here."

Former President Donald Trump falsely claimed Wednesday that polls show his support among Black Americans has quadrupled or quintupled since his mug shot was released.

Tristan Tate reveals he eats 10 raw eggs and smokes a cigarette for breakfast

According to White House staffers, the desk chairs were so far used by men of average height