In a flurry of Friday afternoon activity, Fidelity Investments led a handful of firms that filed a fresh

Police in France are wrapping up the search for a missing toddler after scouring a remote village in the French Alps for five days. Two-year-old Emile was on holiday with his grandparents when he vanished while playing in a garden, sparking a frantic hunt that involved thermic camera drones, helicopters and sniffer dogs. Searches have so far yielded no clues to the whereabouts of the missing boy and police launched a last-ditch bid to find him on Thursday. Here’s a look at everything we know about the case so far. Where did Emile disappear? Emile, whose surname has not been reported, was playing in the garden of a property in Le Vernet - a small village of around 20 houses in the Alpes-de-Haute-Provence on Saturday when he went missing. His family was preparing to go out hiking for the day when they realised the child, who lives near Marseille, had disappeared.The boy’s grandparents had been packing the car when he vanished. Emile is described as 3ft tall, with brown eyes and blonde hair and was wearing a yellow T-shirt, white shorts with a green pattern and walking shoes when he vanished. Reports said he was seen by two people when he left the property but they “lost sight of him”. Police said on Wednesday that at least 10 people were present at the property where Emile was last seen amid a family reunion, with “several uncles and aunts of the child, of all ages, including some minors”, a police source said. How has the search unfolded Authorities in France issued an appeal for information about Emile on 9 July after the boy was reported missing by his grandparents at 5.15pm the previous day. The search operation covered the land and air around Le Vernet and involved hundreds of police officers, soldiers and volunteers, The manager of a local restaurant said staff had looked “everywhere” for the boy as local volunteers helped with the search. “We were preparing for the evening service, when we were told the child had gone missing,” the manager told La Provence. “We all went to see what we could do to help as quickly as possible. “We have looked in places where he could be, we have really looked everywhere for him.” At one point during the search, police helicopters played the voice of Emile’s mother through speakers in the hope that it could help bring him out. On Wednesday evening it was reported that a vehicle with blood on it had been found amid the ongoing search for missing French toddler Emile. In a statement to La Provence, local prosecutor Rémy Avon said analysis had revealed the sample “animal blood”. Emile has now been missing for a week, as investigators admitted they have “no clue” what happened to him. Mr Avon also said that he had taken the decision to call off the “physical” search for Emile on Thursday. Police had been looking at a final plot of land in an area of Vernet, with around 50 officers taking part. “The judicial investigation into the causes of the disappearance will continue,” Mr Avon added. “In particular by analysing the considerable mass of information and elements collected over the past four days.” Police are today combing a 1.8km-long road, that has previously been searched before, in the hope of finding new evidence in Emile’s disappearance. But police say they will be searching the stretch of road more “meticulously” this time. What have politicians said? The mayor of Le Vernet on Friday said the best hope for the missing toddler is that “he’s been kidnapped and is alive”. In an interview with French newspaper Le Figaro, Francois Balique commented on police calling off the physical search for Emile after five days and possible explanation’s for his disappearance. “Our only hope now is that he’s been taken and is alive. It’s the last thing we can hope for and it’s already terrible. “We could consider that someone wanting to cause harm to a child passed by the area, that he saw this beautiful little boy and took him away. He couldn’t survive alone in the wild, that’s for sure.” Mr Balique said it is ”difficult to favour one hypothesis over another” but explained that “the probabilities and the rationality would lead us to believe that we are dealing with an accident”. He continued: “And since little Emile’s body has not been found, it means that he was not alone at the time. We can consider a car accident in which the driver would have panicked and concealed the body. That’s one hypothesis.” Local politician Sylvie Belmontes had earlier said the search reminded her of the case of Yannis Moré, who vanished from Ganagobie, Alpes-de-Haute-Provence in 1989 while playing with friends. “It reminds us of a lot of things. I sent a little message of support to the mayor of Vernet, François Balique”, Ganagobie mayor Sylvie Belmonte told La Provence, referencing the disappearance of 3-year-old Yannis Moré in May 1989. “I was town clerk and I took part in the search to try to find little Yannis”, he added. Mr Avon told a press conference earlier this week that police had “no clue” where the boy was. “His grandparents realised he was no longer there when they went to put him in the car.” What happens next Mr Avon said the previous searches did not yield any clues to solving the mystery of the boy’s disappearance and instead, investigators will be shifting their focus to evaluating evidence already gathered. “The investigation into the causes of his disappearance will continue, notably through analysis of the considerable amount of information and elements gathered over four days,” he added. Read More ‘Best hope’ for toddler missing in French Alps for week is ‘if he’s been kidnapped’ Desperate search for French toddler who vanished on holiday with grandparents Missing French toddler – latest: ‘Only hope is Emile has been taken and is alive,’ Le Vernet mayor says Greece ‘like Africa’ as Europe melts in deadly heatwave forecast to smash record Russian antiwar activist allowed into Serbia after spending more than a day at the Belgrade airport Wagner mercenaries are in Belarus and training the country’s soldiers

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One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Scientist behind Ozempic says drug can make life ‘so miserably boring’ Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications

The Gilgo Beach murders victim previously known only as Jane Doe 7 has finally been identified more than 26 years after her partial remains were first discovered along the Long Island shores. In a press conference on Friday, Long Island officials announced that they had identified the victim as Karen Vergata. Vergata, a 34-year-old woman, was last seen alive in Manhattan in 1996 while working as an escort. Police refused to take any questions and would not comment on whether or not she is linked to serial killer suspect Rex Heuermann. This comes as prosecutors have asked the court to obtain a swab of DNA from Mr Heuermanna and as his wife broke her silence in her first interview since his shock arrest to reveal she is filled with “anxiety” and their two children “cry themselves to sleep” every night over the horror case. Mr Heuermann, 59, was arrested on 13 July and charged with the murders of Amber Castello, Megan Waterman and Melissa Barthelemy. He is also the main suspect in Maureen Brainard-Barnes’ killing. The women all went missing in 2009 and 2010 before their remains were found along Gilgo Beach. Read More Gilgo Beach serial killer suspect’s contact with wife revealed Daughter of Happy Face Killer launches GoFundMe for Gilgo Beach murders suspect’s wife Rex Heuermann’s defence buried in mountain of evidence as he faces court in Gilgo Beach murders case