Former Vice President Mike Pence, the onetime loyal sideman to twice-impeached ex-president Donald Trump, will kick off his own attempt to win election to the nation’s top job this week when he formally announces his campaign at a Des Moines, Iowa event on Wednesday. Mr Pence’s announcement will come just days after he made his candidacy official by filing the necessary paperwork with the Federal Election Commission. The ex-Indiana governor’s presidential ambitions are nothing new, with Mr Pence having teased a presidential run for months during a string of public appearances. But the advent of an actual campaign changes the Republican landscape by putting him in direct competition with Mr Trump, his former running-mate. Mr Pence, 63, served as a member of the House of Representatives between 2001 and 2013 and as Indiana’s governor between 2013 and 2017 but first rose to international attention as Mr Trump’s running-mate in 2016. The pair always made for an unlikely double act, with Mr Pence’s quiet, respectful demeanour and devout evangelical Christian faith utterly at odds with the trash-talking New Yorker’s taste for celebrity, glitzy decor and vulgar showmanship. But Mr Pence remained at his boss’ side throughout his tumultuous one-term presidency, a source of constant support until even his loyalty was tested beyond breaking point by the events of 6 January 2021. After losing the electoral vote to Democrat Joe Biden the previous November by 306 to 232 and the popular vote by 81.3 million ballots to 74.2 million, Mr Trump immediately and baselessly began to insist the contest had been “rigged” in a vast nationwide conspiracy orchestrated by his opponents. Two months of farcical legal proceedings led by a ragtag group of misfit attorneys — most notably among them ex-New York mayor Rudolph Giuliani — ended with a whimper, as Mr Trump’s allies entirely failed to offer a court any argument that satisfied the legal requirements to bring lawsuits challenging the election, much less any proof of the fraud they’d alleged. Increasingly desperate, the president was caught on tape exerting pressure on Georgia’s secretary of state to “find” additional votes in that crucial swing state, before turning his attention to his own deputy, Mr Pence, whom he called upon to weaponise his ceremonial position overseeing a joint session of Congress on 6 January to ratify the election results. Demanding that Mr Pence rule the election results null and void, Mr Trump piled on the public pressure in a series of tweets and in person on the campaign trail, presumably knowing his vice president was reluctant to follow orders. “I hope Mike Pence comes through for us,” Mr Trump said in Georgia. “I hope our great vice president comes through for us. He’s a great guy. Of course, if he doesn’t come through, I won’t like him very much.” Mr Pence refused to comply, instead writing a letter to Congress in which he explained: “I do not believe that the founders of our country intended to invest the vice president with unilateral authority to decide which electoral votes should be counted during the joint session of Congress, and no vice president in American history has ever asserted such authority.” On the day the US Capitol was stormed by enraged Trump supporters attempting to stop the ratification, some participants even erected a gallows and chanted “Hang Mike Pence!” on the National Mall. “To those who wreaked havoc in our Capitol today: you did not win,” Mr Pence responded in the aftermath, sounding far more presidential than Mr Trump. “Violence never wins. Freedom wins. And this is still the people’s house. And as we reconvene in this chamber the world will again witness the resilience and strength of our democracy.” The two men held clear-the-air talks five days after the failed insurrection but their relationship has clearly never recovered. Speaking at a Republican dinner in New Hampshire in June 2021, Mr Pence told his audience: “You know, President Trump and I have spoken many times since we left office. And I don’t know if we’ll ever see eye to eye on that day.” Mr Pence was born in Columbus, Indiana, on 7 June 1959, one of six children born to Edward and Nancy Pence and is a graduate of Hanover College and the Indiana University School of Law. He married his wife Karen in 1985 and the couple have three children: Michael, Charlotte and Audrey. His net wealth has been estimated at $4m, modest compared to some prominent politicians, but has been enhanced post-presidency after he signed a two-book deal with publishing giant Simon & Schuster, thought to be worth around $3-4m, according to industry insiders. Mr Pence will now find himself in competition not only with Mr Trump but also the likes of Florida governor Ron DeSantis, former US ambassador to the UN Nikki Haley, South Carolina senator Tim Scott, entrepreneur Vivek Ramaswamy and ex-radio pundit Larry Elder. Ex-New Jersey governor Chris Christie is expected to enter the GOP primary race this week as well. 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It’s heart-breaking to see a child that’s seriously ill, particularly when they’ve got cancer and might not survive. But children do get the disease – and it’s being highlighted during September’s Childhood Cancer Awareness Month. Fortunately, it’s not common. But every day in the UK, 10 families receive a cancer diagnosis for their child, teenager or young adult, and it’s the leading cause of death in children under 14, according to the charity Children With Cancer UK (CWCUK). However, Jeanette Hawkins, chief nurse at the Children’s Cancer and Leukaemia Group (funded by Young Lives vs Cancer), stresses that childhood cancer isn’t as rare as people might think, with a similar risk as diabetes, epilepsy and bacterial meningitis. “Use of the word rare for childhood cancer is a barrier to diagnosis as both GPs and parents therefore don’t consider it’s possible,” she explains. “Families, on average, have three to five GP visits before cancer is suspected. We need to reduce that by increasing awareness. Remember that childhood cancer is often a constellation of non-specific persistent symptoms, rather than a single ‘red flag’ that would alert a GP. “If you’re worried about your child keep going back.” Christiana Ogunbote, head of research at CWCUK, says childhood cancer accounts for less than 1% of all cancers in the UK, and explains there are 12 main categories of cancers affecting children, with the most common being leukaemia (30%), brain, central nervous system (CNS), intracranial tumours (26%) and lymphomas (11%). Ogunbote says cancer symptoms in children can vary widely depending on the cancer type and where it is in the body, but points out: “Often the individual symptoms of cancer can be similar to common childhood illnesses, so it can be hard to identify. “If a symptom progresses or doesn’t get better as quickly as expected, we would suggest getting it checked out by a medical professional. It’s useful for parents who know what’s ‘normal’ for their child to be aware of the signs and symptoms of cancer, as earlier diagnosis will support better outcomes for children and young people.” Here, Ogunbote outlines the symptoms of the three most common childhood cancers… 1. Leukaemia Symptoms of leukaemia in children and babies, which may be acute myeloid or acute lymphoblastic leukaemia (ALL), can include frequent and persistent infections, unusual bleeding and/or bruising, tiredness, paleness, breathlessness and, with ALL, coughing and anaemia. “Childhood leukaemia develops quickly,” says Ogunbote. “but it’s possible for some or all of these symptoms to be apparent.” She says a leukaemia diagnosis can be made from a blood test, which may reveal low numbers of normal white blood cells and large numbers of abnormal white blood cells. Further tests will then be done on a sample of bone marrow to confirm the diagnosis. 2. Brain and spinal tumours The symptoms of brain and spinal tumours (central nervous system tumours) vary between age groups, says Ogunbote, but symptoms in babies may include persistent/recurrent vomiting, balance/co-ordination/walking problems, abnormal eye movements or suspected loss of vision, behaviour change (particularly lethargy), fits or seizures (not with a fever), abnormal head position such as head tilt or stiff neck, and increasing head circumference. Children’s brain tumour symptoms are similar to symptoms in babies, but may also include a persistent/recurrent headache, blurred or double vision, fits or seizures, reduced consciousness and abnormal growth. Ogunbote says symptoms vary depending on the type and site of the tumour, and develop much more slowly with low grade tumours. But she stresses: “It’s important to remember that many of these symptoms are extremely common, and experiencing one by itself is rarely a sign of a brain tumour.” A CT or MRI scan will be done if a brain tumour is suspected, and if the scan confirms the diagnosis, further investigations will determine the type of tumour and best treatment. 3. Lymphoma Children may get a cancer of the lymphatic system known as either Hodgkin or non-Hodgkin lymphoma, and Ogunbote says symptoms of both include a persistent (lasting a few weeks) painless swelling of a single lymph gland, usually in the neck, or possibly in the armpit or groin with non-Hodgkin, a cough or breathlessness (if glands in the chest are affected), fevers, sweats, and weight loss. There may be itching with Hodgkin lymphoma, and with non-Hodgkin there may be tiredness, feeling full after a small meal, stomach pains (if abdominal lymph glands are affected), and sleep sweats. Diagnosis is confirmed by removing part or all of an affected lymph gland, usually under general anaesthetic, and doing a biopsy on it so the cells can be examined in a laboratory. Further tests, like x-rays, CT and MRI scans and blood tests, will also be carried out to determine the size and position of the lymphoma and whether it has spread. This is known as staging. “Many of the symptoms of lymphoma can also be symptoms of other illnesses, so this can make it difficult to diagnose,” explains Ogunbote. “Symptoms your child might experience depend on where the lymphoma is in their body, and symptoms vary from child to child, even if they have the same type of lymphoma.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 4 viral TikTok make-up trends you’ll actually want to try Daily aspirin dose could help prevent diabetes in older people – researchers Secondhand September: The best places to buy pre-loved fashion online

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A manhunt is under way to track down a second suspect wanted in connection to a mass shooting that left nine victims – including four children – injured on Memorial Day. The shooting unfolded at about 6.15pm local time near the beach boardwalk in Hollywood, Florida, on Monday as families and friends gathered to enjoy the holiday. Police said that a fight is believed to have broken out between two groups on the seafront, which then escalated into gunfire. At least nine people were injured in the mass shooting, including a one-year-old baby and a 17-year-old. Hollywood Police Department spokesperson Deanna Bettineschi said one victim was in surgery late on Monday while the others were stable. One person has been detained following the incident and a second suspect is now on the run from authorities. He is described as a Black man with dreadlocks who was wearing a black short-sleeve shirt and camo shorts. Chilling video take on the boardwalk shows terrified crowds fleeing the busy boardwalk as the gunfire erupted near a convenience store, a Ben & Jerry’s ice cream store and a Subway sandwich shop. Read More At least nine people wounded in Memorial Day mass shooting at Florida beach Video shows tourists fleeing Miami beach in terror at mass shooting Ron DeSantis news – live: DeSantis facing three new lawsuits as Trump blames him for making Disney ‘woke’

Authorities say a pilot escaped with only minor injuries after a single-engine plane crashed nose-first into the roof of a hangar at a Southern California airport