By Alexandra Ulmer and Tim Reid LAS VEGAS (Reuters) -Former U.S. Vice President Mike Pence ended his cash-strapped presidential campaign

A tourist has died and another has serious injuries after a man threw them off a bridge into a ravine at a famous ‘fairytale’ German castle. The American tourists, aged 21 and 22, fell 165ft down a ravine at Neuschwanstein, near the Austrian border. According to German tabloid Bild, the attacker was also American and aged 30. Police said the man fled but was arrested after the incident on Wednesday. The 30-year-old attacker reportedly sexually assaulted the two women before a fight broke out. When the 22-year-old intervened, the man strangled her and threw her into a ravine below, the BR public broadcaster reported. According to reports, the women were either thrown over the railing or pushed down a steep slope into the ravine. A 21-year-old woman was rushed to hospital via helicopter but died overnight in hospital. Her 22-year-old companion is still in hospital with injuries. Chief Public Prosecutor Thomas Hörmann told Bild: "The crime happened on Wednesday around 2:40pm. The two tourists met the man on a hiking tour east of the Marienbrücke. And joined him. The attack took place near the Marienbruecke, a bridge over a gorge close to the castle that offers a famous view of Neuschwanstein, German news agency DPA reported. Authorities said the three apparently took a path to a viewpoint, where the man attacked the younger woman. The suspect was caught after a massive police operation involving 25 emergency vehicles on Wednesday afternoon and taken to a police station in nearby Fuessen, it added. Neuschwanstein is one of Germany's most popular tourist attractions and is said to have been the inspiration for the Disney Cinderella Castle. The motive for the attack is still unclear and all parties remain unnamed. Read More Daniel Penny’s legal defence has raised more than $2.8m after subway killing of Jordan Neely Closings arguments set in trial of gunman in Pittsburgh synagogue massacre Nottingham attack – latest: Suspect in horror killings went to same university as victims

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Ron DeSantis gave his first 2024 campaign rally at an Iowa megachurch on Tuesday - attacking a predictable list of foes, including the federal government and its bureaucracy, Dr Fauci and Disney. “No excuses, I will get the job done,” the Florida governor told the audience at Eternity Church on 30 May 30, in Clive, Iowa as he warned Republicans that they faced a Democratic sweep in 2024 if they did not learn to win elections again. Earlier Mr DeSantis attacked his rival Donald Trump by saying “he’s taking the side of Disney in our fight down here in Florida. I’m standing for parents, I’m standing for children.” Meanwhile, Florida attorney Michael Sasso, chosen by Mr DeSantis to be part of the Central Florida Tourism Oversight District – given responsibility for Walt Disney World’s special tax district in legislation passed in February – has resigned just three months after taking the job. This comes with Mr DeSantis facing three new lawsuits after he signed a new law just hours before announcing his presidential campaign last week making it harder to vote in the Sunshine State. Read More Culture wars, parenting and tiptoeing around Trump: Five takeaways from Ron DeSantis’s 2024 launch Ron DeSantis called out for ‘ignoring’ Hollywood beach shooting: ‘He doesn’t care’ DeSantis hits familiar targets of Fauci, Disney and ‘wokeism’ in first rally as 2024 candidate

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Surgeons worked all day and into the night to ensure Britain’s first womb transplant went smoothly. Its success is down to meticulous research, years of sharing knowledge between experts around the globe, and the hard work and dedication of doctors Professor Richard Smith, from Imperial College London, and Isabel Quiroga, from the Oxford Transplant Centre. Around 50 babies have been born worldwide as a result of womb transplants, which give women missing a functioning uterus a chance to have a baby. In the first UK case, the operation to remove the womb from the recipient’s 40-year-old sister lasted eight hours and 12 minutes, with surgeons leaving her ovaries behind to prevent pushing her into early menopause. One hour earlier, surgeons began operating on the 34-year-old recipient, preparing her body to receive the donated organ. This operation lasted nine hours and 20 minutes, with the surgical team experiencing some difficulties including a higher-than-expected blood loss of two litres. However, after just 10 days, the recipient was well enough to leave the hospital and has continued to have a good recovery. She is also having regular periods, which shows the womb is working well. Her sister was discharged five days after her donor operation and has also made a good recovery. Removing a womb is a similar operation to a radical hysterectomy, according to Prof Smith, who as well as being a gynaecological surgeon is the clinical lead at the charity Womb Transplant UK. He and Miss Quiroga led the team of more than 30 staff who worked on the transplant one Sunday in February. Prof Smith and Miss Quiroga removed the older sister’s womb, cervix and fallopian tubes, plus crucial blood vessels around the organ. The main vessels are the uterine arteries running into the womb, but the surgeons also aimed to collect some of the larger internal vessels that lead into the smaller branch of the womb. Prof Smith said surgeons doing these operations have to retrieve veins involved in the drainage of the womb. “One of the amazing things is that my surgical skill-mix as a cancer surgeon is to remove organs with a margin of normal tissue, while sealing the vessels as I go,” he said. “Transplant surgical skills are different – that is to remove a normal organ with the best number of non-sealed vessels as you can. “Isabel and I operate together with no ego – it just flows backwards and forwards across the table.” He added: “The day itself was truly humbling. We turned up at 7am at the Churchill transplant centre with the donor and the recipient families, then we went into a pre-op huddle. Those in the huddle included surgeons, nurses, anaesthetists and technicians. Prof Smith and Miss Quiroga worked to remove the womb, before the organ was prepared for transplantation by a “back table” team. “This was an organ which had a very, very unusual blood supply,” Prof Smith said. “In fact, it had a set of blood vessels which I’ve never seen in my entire career. They made my dissection a bit harder than it might have been, but we got there.” In the theatre next door, one hour before the retrieval of the womb was completed, surgeons began to operate on the donor’s younger sister to enable her to receive the womb. Prof Smith and Miss Quiroga switched from donor to recipient and Prof Smith removed the vestiges of the underdeveloped womb the recipient was born with. Meanwhile, the organ was packed and transported between the two theatres under sterile conditions to prevent contamination. A sterile bag with a cold perfusion solution contained the womb, which was then placed into a container with ice. During surgery, ligaments attached to the womb were attached to the recipient to help the womb stay in a relatively fixed place so it does not move around the pelvis. The most important part of the transplant operation was the joining of the very small vessels that give the blood supply to the womb. This was the most delicate and difficult part of the operation and was led by Miss Quiroga. Once all the vessels were connected, the donor’s vaginal cuff – around a 1cm part – was stitched into her sister’s vagina. If and when the recipient is able to complete her family, the womb will be removed six months later to prevent her from needing immunosuppressants for the rest of her life. Prof Smith said: “We know that the chance of failure at the point where the uterus goes in – if you look at the world literature – is 20 per cent to 25 per cent. And that failure is usually on the basis on sepsis and thrombosis. So technically, we are up to the job, but what happens thereafter can be scary. “Once you get to three or four days later, the chance of failure drops to probably less than 10 per cent. “Once you get to two weeks – and at the point where the woman has a period – the chance of her having a baby at that point is very high and the chance of failure has dropped to low. But those first two weeks – it’s very scary as a surgeon to watch and wait.” Biopsies to check the womb was functioning were read in London but then also confirmed by an expert team in the US at Baylor University Medical Centre in Dallas, where other womb transplants have been performed. Prof Smith said the procedure gives new hope to women born with devastating conditions. He said: “You’ve got girls, maybe 14, who have not had periods, they go to the GP and a scan shows there is no uterus. Absolute catastrophe. “Up until now, there’s been no solution for that, other than adoption or surrogacy... That’s not the case now. It’s really exciting.” On whether transgender women may also benefit from the operation, Prof Smith said that was still a long way off. He said the pelvic anatomy, vascular anatomy and shape of the pelvis are different, and there are microbiome issues to overcome. “My own sense is if there are transgender transplants that are going to take place, they are many years off. There are an awful lot of steps to go through. My suspicion is a minimum of 10 to 20 years.” Miss Quiroga said the living donor programme to date in the UK has focused on women with relatives who are willing to give their wombs. “It will come to a point where we will have friends or altruistic donors, like we have with many other transplants, but at the moment we’re only focused on people who have come forward with relatives,” she said. 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