At least eight people, including children, were killed after a building collapsed in Brazil's northeastern state of Pernambuco on Friday, according to CNN affiliate CNN Brasil, citing the state's Secretariat of Social Defense (SDS.)

TikTok and Meta are filing legal challenges against new European Union rules designed to counter the dominance of digital giants and make online competition fairer by giving consumers more choice

UK inflation is becoming more “home-grown” and will be “challenging to squeeze out of the system,” according to

Apple released a significant security update for iPhones and iPads Thursday to patch newly discovered security vulnerabilities in the devices' system software

Officials and investors are starting to worry that the world is sliding toward a new era of great-power

Andrew Tate provoked Eminem fans by criticizing the rapper after a fan asked for his opinion on a clip featuring his music

A gauge of Chinese high-yield dollar debt fell to the cusp of distress after one of the most

By Agnieszka Pikulicka-Wilczewska WARSAW (Reuters) -Poland said on Tuesday it was rushing troops to its eastern border after accusing Belarus,

One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Scientist behind Ozempic says drug can make life ‘so miserably boring’ Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications

The move comes after some Indian cough syrups were linked to deaths in The Gambia and Uzbekistan.

Police in the Netherlands arrested over 3,000 climate activists this week during ongoing protests against government subsidies given to planet-heating fossil fuels. Extinction Rebellion, the organisation which called for protests, said this is the highest number of arrests they have faced from a single demonstration. “It's the most we have ever had," Hester Op De Laak, a representative of Extinction Rebellion told The Independent. She said around 2,400 people were arrested on Monday alone, with several hundred arrests taking place on Saturday and Sunday. The protests continued on the fifth consecutive day on Wednesday with hundreds of people blocking a major highway which connects to The Hague, the seat of the Dutch government. Local police said activists marched onto the A12 highway and blocked all incoming traffic to the city, the news agency ANP reported. Authorities said they warned protesters to stay off the road and detained people who ignored orders to leave. The group said it would continue till the Dutch government stopped using public funds to subsidise the oil and gas industry, as they have done in recent months. All the detained protesters have been released after being removed from the scene, the authorities said. On Monday, the police deployed water cannons to disperse the crowd, with photos and videos showing activists drenched in water and some being taken off the scene. No injuries have been reported, authorities said. “25,000 People Block Amsterdam A12 Motorway,” said Just Stop Oil on Monday, another group of climate activists, sharing a video of protestors holding banners as police fired water cannons. In one video, activists could be heard chanting: “What do we want? Climate justice!” On Saturday an estimated 10,000 activists joined the protest, while on Sunday several hundreds blocked the road, Reuters news agency reported. Earlier this year in May, 1,579 protestors of Extinction Rebellion were arrested from the same spot. The police released most of them but said 40 people would face charges. Over 1,000 arrests took place in the UK in 2022 after climate protestors blocked oil terminals. According to a report published last week by the Center for Research on Multinational Corporations, these subsidies total around €37.5bn (£32.23bn) each year. Burning fossil fuels – such as coal, oil and gas – is responsible for the majority of carbon pollution that is heating the world and fuelling more extreme weather and disasters. Scientific assessments have found that the global average temperature has already risen by about 1.2 degrees Celsius and it is set to rise more, triggering worse extreme heatwaves, droughts, hurricanes and wildfires. The year 2023 has seen the hottest summer on record, the United Nations confirmed this month with temperatures between June to August standing at 1.5C higher than normal. Read More Climate activists attack Walmart heiress’ $300m yacht – again What we know about 2023 Burning Man’s flooding chaos Hurricane Lee tracker: Alerts issued across coastal New England Just Stop Oil: Are the climate group’s demonstrations at sporting events against the law? Sadiq Khan says Just Stop Oil ‘really important’ amid Pride parade sponsors row UK police have new expanded powers to crack down on protests

'The country loved Dave (David Letterman) and Jack Hanna together. Their chemistry was magnetic and friendship completely genuine,' a source said