Stating 'today is a victory,' Sekyiwa Shakur said the family is 'seeking real justice, on all fronts'

Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all possible “missense” variants in genes, identifying whether they are likely to cause diseases or benign. That compares with just 0.1 per cent of all missense variants that have been confidently classified by human experts. Missense variants happen when a single letter is substituted in the DNA, which in turn leads to proteins with a different amino acid. That small change can have significant effects – Google likened it to the way that changing a letter in one word can change the meaning of the whole sentence. Most of those variants are benign: the average person has more than 9,000 of them. But some of them can be disastrous, leading to rare genetic diseases. The new AlphaMissense looked at existing information about missense variants, and how commonly they are seen in humans and closely-related primates. It looked for those that were rarely seen, classifying them as pathogenic, and from that was able to use that information to analyse other protein sequences – giving not just a verdict on whether they were likely to cause problems, but also how confident it was. Experiments, conducted by humans, which look to find those mutations are expensive and slow: they require people to examine each unique protein and designed separately. Google says that the new system means that researchers can “preview” those results for thousands of proteins at a time, helping them decide where to focus. The company has used its systems to release a vast catalogue of “missense” mutations, so that researchers can learn about what effect they have. In some cases, those variations can lead to conditions such as cystic fibrosis, sickle-cell anaemia, or cancer, and understanding them could be key to researchers studying ways to treat or prevent those diseases. It is just the latest health breakthrough from Google’s Deepmind division, which is looking to use artificial intelligence to both identify and treat a variety of conditions. The new system was built on AlphaFold, the breakthrough model that helped unfold proteins, the building blocks of life. The research is described in a new paper, ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’, published in the journal Science. The catalogue is being made “freely available to the research community”, Google said, and the company will release the code behind the AI system. Read More BBC removes some Russell Brand content as monetisation suspended on YouTube Google Bard can now link to Gmail and other apps to help with responses Long-form video content is here to stay, says YouTube UK boss

By Nidal al-Mughrabi and Steve Holland GAZA U.S. President Joe Biden flies to Israel on Wednesday to signal

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Firefighters and civilians battling the nine-day wildfires ravaging Rhodes are contending with continuous flare-ups fuelled by unpredictable winds, as temperatures neared a scorching 40C. Greece’s civil protection agency extended the state of emergency across the entirety of Rhodes on Wednesday, which will remain in place for six months, “to deal with emergencies and manage the consequences of catastrophic forestry fire”. In the town of Malonas, which was evacuated on Saturday, The Independent watched on alongside exhausted volunteers as a section of the charred forest nearby reignited. The handful of volunteers gathered outside St George’s Church stood up to watch as a firefighting plane flew overhead, dousing the flames in water – as smoke continued to rise skywards. They expected to venture out again alongside hundreds, if not thousands, of other civilians on Wednesday night to do what they could to keep the fires at bay – having fought back the flames as they encroached on the sleepy inland town just the night before. “We have no energy, we have no power – not enough to stop this ... We are waiting for the wind to calm down to try again tonight to finish the job, but it is very difficult because after 10 days everyone is very tired,” a volunteer named Panos said, adding: “I’m going to sleep now for one hour.” He spoke as firefighters were mobilised to the nearby village of Apollona, while fires also burned further south in Vati and Gennadi. “The fires have started again,” a fire service official told The Independent. “A little wind and the fire returns … That’s the problem.” Having been told to evacuate both Malonas and nearby Kalathos at the weekend, Miles and Tristan, both in their 50s and originally from England, returned to Tristan’s house in Malonas on Wednesday to bring his four cats home. After receiving the “stressful” emergency alert telling them to leave Kalathos for either Kallithea – which they felt at the time was unsafe – or Lindos, where locals had already been told it was safe to return and where they knew a hotel manager who could put them up for the night. “Even if we’re just camping down on sofas in the hotel reception, it’s shelter, whereas if we went to Kallithea we would literally be on the street,” said Tristan. Speaking in the entrance to Tristan’s home as a firefighting plane flew overhead, dropping water a short distance away, the pair said they now planned to stay put. “We’re fed up with it now,” said Miles, an artist who has lived in Rhodes for 17 years. Tristan added: “Also, now [the authorities] are willing to allow everyone to help [keep flare-ups at bay], whereas before they just didn’t want the complications of it – non-Greek speakers being where they are [with] no skills, no car. I haven’t even got boots. They said ‘what are you going to do: walk over the ground in trainers? They’re just going to melt.” Describing a “pattern” of flare-ups each afternoon, Tristan said: “It’s been almost identical for three days, it’s really weird.” Miles added: “Clear in the morning. By the afternoon, the sky’s gone dark ... there’s smoke everywhere, and you can see it for miles.” However, the skies remained clear as they spoke – prior to the individual flare-up witnessed by The Independent some 15 minutes later. “That’s why the helicopters are flying over now, they’re damping down near the edges to try and make sure it doesn’t come back,” said Miles. Read More Infernos, black skies and fleeing tourists: Greece wildfires in pictures as blazes ravage Corfu and Rhodes Summer holidays to fire-hit Rhodes on sale for just £295 – half the usual price Tragic 'last words' of hero pilots who died in plane crash fighting Greek wildfires Tourists flying into Greece inferno reveal why they refuse to cancel holiday

The fears of this year’s World Series between the Texas Rangers and Arizona Diamondbacks becoming the least-viewed Fall Classic in TV history are becoming a reality

By David Shepardson and Steven Scheer WASHINGTON (Reuters) -The U.S. State Department will begin offering charter flights to Europe to

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