By Deena Beasley SAN DIEGO Drugmaker Novo Nordisk on Sunday said a late-stage trial found that a high-dose

By Howard Schneider WASHINGTON (Reuters) -Rocketing U.S. government bond yields that have led to a global jump in borrowing costs

The suspect in a hostage standoff at Caesars Palace has been identified as 35-year-old fugitive Matthew Mannix, according to Las Vegas Metropolitan Police Department. A probable cause affidavit obtained by The Independent revealed that Mr Mannix was experiencing “drug-induced” schizophrenia when he allegedly held a 26-year-old woman hostage inside a room on the 21st floor of the resort on Tuesday. Hotel security first informed authorities of a domestic dispute in room 2128 around 9.30 PDT. Mr Mannix was arrested nearly five hours later after allegedly claiming that he “had a magazine full of rounds” and “would pull the trigger” — no mention of firearms recovered from the scene was made in official records. He was charged with kidnapping in the first degree, coercion with force, destroying property, resisting arrest without a firearm and disregard for the safety of a person. Following Mr Mannix’s arrest, the hostage victim told law enforcement that she was afraid to leave the room because her alleged captor had a knife and she also thought he would throw her out of the window he broke in the room. According to the incident report, Mr Mannix and the victim previously knew each other and had been experiencing a “transient lifestyle” on the Las Vegas strip and binging on narcotics for several days. As crisis negotiators talked with Mr Mannix, he allegedly spoke over the woman and threatened to “cut her tongue out of her mouth” so she wouldn’t engage with law enforcement at the scene. After she was rescued, police noted that the victim had cuts and bruises on her legs, some of which could have been caused by a beating. Employees at Caesars Palace first tried to check on the guests after receiving several complaints of noise coming out of room 2128, which they believed to be a domestic dispute. When security approached the room, they reportedly found a man believed to be Mr Mannix barricaded inside and threatening to “shoot someone” if police tried to breach the room. The threats continued and at some point, a female also yelled that the man “had a knife.” Las Vegas Police, a SWAT team and medical responders arrived at the scene to handle the hostage situation. Mr Mannix reportedly refused to let the 26-year-old woman out of the room and continued to open and close the door while allegedly threatening to “pull the trigger.” The woman eventually attempted to reach the door, but Mr Mannix then allegedly dragged her to the bed “as he body slammed her ... and began to have intercourse with her.” Mr Mannix is also accused of throwing large objects out of the window of his hotel room, sending guests on the pool deck running for cover. Bystander video showed broken glass and debris littering various decks at the Caesars as guests ran for safety. An investigator noted that the pool deck was left littered with furniture and glass and the property damage inside the room was “some of the most severe I have seen in my 18 years as a detective.” The damage caused is estimated to be upwards of $50,000. Mr Mannix was finally taken into custody at 2.40pm PDT. He reportedly told investigators during questioning that the victim was her “girlfriend and he loved her” and that “he would pay for everything that he damaged.” “[Mr Mannix] was so high that he was paranoid and had a schizophrenic episode where he was yelling random comments and numbers and saying that he would pay for everything because he has a lot of money,” the affidavit read. Las Vegas police also said that Mr Mannix is wanted in Colorado and has four protection orders against him. He appeared in court on Wednesday and his bail was set at $750,000. Mr Mannix is being held at the Clark County Detention Center. Read More Suspect in Caesars Palace hostage standoff identified as wanted fugitive Matthew Mannix - live Caesars Palace hostage-taker named as fugitive Matthew Mannix

Donald Trump was in attack mode as he spoke to supporters Saturday evening in Columbia, South Carolina. The former president, not known for holding back against his enemies, was more combative than ever as he spoke at a South Carolina Republican Party fundraiser in the wake of his indictment on criminal charges related to his attempt to overturn the 2020 election. While some moments were clearly scripted and focused his rage against President Joe Biden and the Department of Justice, others were not as he veered into attacks against Senate Minority Leader Mitch McConnell and Republicans tied to leadership in the Senate who have resisted his calls to use their power to help him — both on January 6, and now, as he faces criminal prosecution. “These guys, what they’re doing with this election interference ... the Senate needs to step up. The House is doing a lot of things…They have something on Mitch McConnell,” the former president argued, presumably meaning either Democrats or the Department of Justice, or both. “There’s no way he’s doing this. They got something on Mitch McConnell.” It was the kind of blunt attack, launched from the backyard of Senator Lindsey Graham, that is likely to cause further headaches for the Senate GOP caucus, which mercifully can avoid reporters’ questions about the matter until the end of the August recess. Mr Graham has traded blows publicly with McConnellworld in recent months, earning a vicious rebuke and accusations of flip-flopping from a former top aide to the Senate GOP leader. The remark could also be awkard for Senator Tim Scott, the other member of South Carolina’s Senate delegation, who is running against Mr Trump for the 2024 Republican presidential nomination but has yet to take a strong line of attack against the former president. Mr Trump’s remarks about the House of Representatives “doing a lot of things” refers to the efforts by the House Judiciary Committee to battle the Department of Justice as well as prosecutors in Manhattan over their offices’ respective prosecutions of Mr Trump; those actions by the Judiciary panel, however, have largely amounted to show and have done little if anything to hinder the investigations themselves. Given the Democratic majority in the Senate, it’s not clear what else the president has in mind for his allies to accomplish. Some individual senators have taken to blocking appointments to various federal agencies until their demands are met, but these actions have not yet been undertaken or endorsed by GOP leadership. Others attacked by Mr Trump during his speech on Saturday included his former attorney general, Bill Barr, who has affirmed in public interviews that he believes the Department of Justice’s prosecutions of his ex-boss to be legitimate and serious, and Jack Smith, the special counsel leading the Department of Justice’s prosecution of Mr Trump in two matters: The alleged unlawful retention of classified material and other presidential records, and the campaign to overturn the election ending on January 6. His most scripted attacks were predictably aimed at Mr Biden however, whom he accused once again of using his power to enrich himself and his family. The charge has been leveled at his own family in the wake of their departure from the White House, in particular given a massive Saudi-backed investment into his son-in-law Jared Kushner’s business secured shortly after the end of his time in government. “Crooked Joe Biden only cares about enriching his family,” Mr Trump said. “I care about enriching your family.” “Under my leadership, we built the greatest economy in the history of the world,” said the former president.“When I get back in office, I’m going to reverse Bidenomics and restore the trajectory I created toward increasing this country’s financial prosperity.” Mr Trump was in Washington this past week for his indictment on charges related to the 2020 election. He entered a plea of not guilty as the number of criminal counts formally filed against him continued to climb, and immediately began making statements about the investigation that have forced prosecutors to seek a protective order from the judge that would limit what he can say publicly. He continues to persist as the far-and-away leader of the Republican 2024 primary field, even as it appears likely that he and/or members of his legal team could face further charges filed against them later this month in Georgia as a grand jury investigation into his efforts to change election results in that state comes to a head. The former president and his allies continue to wrongfully insist that the 2020 election was “stolen” by Mr Biden even as every reputable expert and agency with authority to monitor elections have said that his claims about the results are false. Read More DeSantis steps up dire warning to GOP about distraction from Biden, amid Trump's latest indictment Trump attacks ‘delusional’ Pence over key role in election indictment: ‘Gone to the dark side’ Mike Pence heckled by Trump supporters at town hall after rolling out mocking merch Trump goes on kooky rant about how long it takes to wash his ‘gorgeous head of hair’ Vivek Ramaswamy's Hindu faith is front and center in his GOP presidential campaign Trump demands Judge Tanya Chutkan be removed from election case after ruling against him

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