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Sepsis is an illness that affects nearly 50 million people worldwide each year, with around 11 million deaths attributed to the condition. In the United States, at least 1.7 million adults in the US develop sepsis annually, and nearly 270,000 die as a result, the Centres for Disease Control and Prevention (CDC) says. It affects 245,000 people in the UK each year, with around 48,000 deaths, according to the UK Sepsis Trust. World Sepsis Day commemorated on 13th September every year, strives to raise global awareness of the life-threatening condition. The day is seen as “an opportunity for people worldwide to unite in the fight against sepsis,” the Global Sepsis Alliance says. Here is everything you need to know about sepsis: What is sepsis? Sepsis Research says when the condition strikes, the immune system “overreacts” and begins to attack the infection and everything else around it “including the body’s own tissues and organs.” “Any type of infection — bacterial, viral or fungal — can lead to sepsis,” it adds. When sepsis occurs, it can cause inflammation and cause blood clotting around the body, if it does not get treated, it can result in death, organ failure and tissue damage, CDC says. Sepsis cannot be caught from another person, the NHS explains. What are the symptoms? The World Health Organisation (WHO) explains that the condition is a “medical emergency,” so if you think a person is exhibiting signs of sepsis or if you are showing signs – make sure you call 999 or go to the emergency room immediately. According to WHO, common signs and symptoms include: • Fever or low temperature and shivering • Confusion • Difficulty breathing • Clammy or sweaty skin • Extreme body pain or discomfort • High heart rate, weak pulse or low blood pressure • Low urine output Symptoms in children include: • Fast breathing • Convulsions • Pale skin • Lethargy • Difficulty waking up • Feeling cold to touch What are the causes? The Mayo Clinic says any type of infection can lead to sepsis and those that more commonly cause the condition include infections of: • Lungs, such as pneumonia • Kidney, bladder and other parts of the urinary system • Digestive system • Bloodstream • Catheter sites • Wounds or burns “Sepsis often presents as the clinical deterioration of common and preventable infections such as those of the respiratory, gastrointestinal and urinary tract, or of wounds and skin. Sepsis is frequently under-diagnosed at an early stage - when it still is potentially reversible,” the Global Sepsis Alliance says. Who is most at risk? The people most at risk of the condition, according to Mayo Clinic, are: • People with lower immune response, such as those being treated for cancer • People with human immunodeficiency virus (HIV). • People with chronic diseases such as diabetes kidney disease or chronic obstructive pulmonary disease (COPD). • people who are in intensive care or longer hospital stays. • People over the age of 65 • Infants How many cases are there globally? The WHO says a scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20 per cent of all global deaths. That same year, almost half of all global sepsis cases occurred among children with an estimated 20 million cases and 2.9 million global deaths in children under 5 years of age. How can it be prevented? The Global Sepsis Alliance says the best to to avoid sepsis is by preventing infection. This can be done by undergoing vaccinations, ensuring that you only come into contact with clean water, washing your hands properly and if you are giving birth - making sure it is in a clean and sterilised environment. Can sepsis be treated? Sepsis can be treated with appropriate treatment such as antibiotics – this should be given as soon as possible. The CDC says sometimes “surgery is required to remove tissue damaged by the infection”. “Antibiotics are critical tools for treating life-threatening infections, like those that can lead to sepsis,” the CDC adds. Read More 5 things everyone needs to know about eczema 13 potential cancer symptoms you should get checked out How can I improve my teenager’s low mood? Duran Duran’s Andy Taylor says he’s ‘asymptomatic’ after end-of-life diagnosis Nine hours of parallel surgery: how Britain’s first womb transplant was carried out Bursts of activity that make you huff and puff ‘linked to reduced cancer risk’

Incessant rain failed to put a damper on Nicolas Ghesquiere’s ambitions for his Louis Vuitton 2024 Cruise collection, unveiled to an A-list crowd including Oprah Winfrey, Cate Blanchett, Jennifer Connelly and Emma Stone

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Elon Musk wants to turn Twitter into a “digital town square,” but his much-hyped Twitter Spaces kickoff event, with Florida Gov. Ron DeSantis announcing his run for president, struggled with technical glitches and a near half-hour delay Tuesday

(This May 8 story has been refiled to correct a misspelled word in paragraph 7) By Andrew Goudsward (Reuters) -

Authorities investigating the shootings of two Alabama firemen, one fatally, are offering a $45,000 reward for help finding a suspect.

On President Joe Biden's 81st birthday, GOP front-runner Donald Trump has released a letter from his physician that reports the former president is in “excellent” physical and mental health

As the probe into whether former President Donald Trump or his advisers broke the law in their retention of documents including some potentially classified material from the White House nears its end, Mr Trump’s legal team is said to be fearing disloyalty. The Daily Beast reported on Tuesday that the former president’s attorneys supposedly worry that some among them may decide to start talking to the Department of Justice, becoming witnesses in the case, as the attention of the agency turns to the actions of the legal team themselves. The probe into Mr Trump’s handling of presidential records, including classified documents, exploded into the public eye last year when FBI agents raided Mar-a-Lago, Mr Trump’s home and resort in Florida. Several current attorneys to Mr Trump who serve in varying capacities described a chaotic situation where much of the strategy is managed by Mr Trump’s in-house counsel, Boris Epshteyn, and clashing personalities have led to a toxic environment — all of which is occurring as the Justice Department’s special counsel is said to be closing in on a decision regarding potential criminal charges in the case. More follows... Read More Ivanka and Jared split over attending Trump 2024 launch – follow live Why was Donald Trump impeached twice during his first term? Four big lies Trump told during his 2024 presidential announcement

In the hurly-burly outside one of Tokyo's main train stations stands a statue of a dog whose true story of loyalty has made him...