The morgue manager at America's prestigious Harvard Medical School allegedly took dead body parts from his workplace without permission and then sold...

Racing will resume at Churchill Downs in September, with no changes being made after a review of surfaces and safety protocols in the wake of 12 horse deaths

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

In a viral livestream conversation, Kai Cenat's mother discovered his 'ZaZa' challenge during a 24-hour stream with Offset

Three people were killed in a Russian attack on the Ukrainian city of Zaporizhzhia on Wednesday, Ukrainian President

China’s capital reported its first mpox infections and local health authorities have started an investigation to trace its

Britney Spears' tell-all book 'The Woman in Me' has fans eagerly anticipating a possible biopic based on it

Niger’s mutinous soldiers say they will prosecute deposed President Mohamed Bazoum for “high treason” and undermining state security, hours after they said they were open to dialogue with West African nations to resolve the mounting regional crisis. The announcement on state television on Sunday night, by spokesman Col. Maj. Amadou Abdramane, said the military regime had “gathered the necessary evidence to prosecute before competent national and international authorities the ousted president and his local and foreign accomplices for high treason and for undermining the internal and external security of Niger.” Bazoum, Niger’s democratically elected president, was ousted by members of his presidential guard on July 26 and has since been under house arrest with his wife and son in the presidential compound in the capital, Niamey. People close to the president as well as those in his ruling party say their electricity and water have been cut off and they’re running out of food. The junta dismissed these reports Sunday night and accused West African politicians and international partners of fueling a disinformation campaign to discredit the junta. International pressure is growing on the junta to release and reinstate Bazoum. Immediately after the coup, the West African regional bloc ECOWAS gave the regime seven days to return him to power or threatened military force, but that deadline came and went with no action from either side. Last week, ECOWAS ordered the deployment of a “standby” force, but it’s still unclear when or if it would enter the country.

Andrew Tate's recent tweet showcases him deviating from his rants and talking about love

Republican Gov. Glenn Youngkin of Virginia had made clear his Election Day expectations

WASHINGTON U.S. consumer prices rose modestly in June and registered their smallest annual increase in more than two

It was a Sunday night and a young couple were sitting together in a car at a park near Los Angeles. What happened next was something straight out of a horror movie – except this was real life. A gunman suddenly opened fire on the couple before pulling 19-year-old Andrea Vazquez from the car. Vazquez’s boyfriend escaped the gunfire but returned to the vehicle to find she had been kidnapped. After an intensive one-day search, the harrowing incident culminated in despair as Vazquez’s body was found in a field and a suspect – who has no known connection to the couple – was arrested for her murder. Heartbroken relatives described Vazquez as a “beautiful person” as they have been left struggling to understand what happened and why. Here’s everything we know so far about her abduction and death: A chilling abduction The horror unfolded just after midnight on Sunday 20 August when Vazquez and her boyfriend were sitting in a car at Penn Park in Whittier, police said. Her boyfriend told police that an armed suspect then approached their vehicle and “fired a weapon in their direction,” police said. Vazquez’s boyfriend fled the scene and when he returned he discovered blood near his car and his girlfriend missing. Vazquez has been kidnapped from the scene. Officers were alerted to a shooting and kidnapping incident located at the “parking stalls area” at 13950 Penn Street in Whittier. In a statement following her kidnapping, police said that Vazquez was last seen wearing a black long-sleeve crop top, khaki pants, and black low-top Converse shoes. “She has a tattoo of ‘Edlyn’ on the back of the neck, Aries constellation on the top of her right hand and a belly button piercing,” the statement read. Vasquez’s sister, Edlyn, with whom she lives in Los Angeles, put out a plea on Facebook for the public’s help in finding her. “My sister was shot and kidnapped at Penn Park,” she wrote. “Her last location shows Moreno Valley. We don’t know her condition. Please I am begging, if anyone has information, or the heart to share this, please please contact me and repost.” Another relative Emily Martinez told Fox News Digital that Vasquez’s phone last pinged in the Moreno Valley area. “We’re scared for her, but I’m hopeful, very hopeful that we’ll find her,” she said. “We just want to know she’s OK.” Tragic discovery Following the horror kidnapping, a huge search was launched to try to find the missing 19-year-old. That search ended in tragedy on Monday 21 August when, at around 11.50pm local time, authorities combing the area of Moreno Valley made a gruesome discovery. Police said that the teen’s body had been found in a vegetation field off Alessandro Boulevard and Merwin Street in Moreno Valley. It is currently unclear how she died or the nature of the scene where her body was found. The investigation remains ongoing but police said that it appears that the attack on Vazquez and her boyfriend was “randomly targeted”. The ‘random’ suspect On Tuesday 22 August, police announced an update on the case as a suspect was taken into custody. Detectives from the Whittier Police Department and the LADA Community Violence Reduction Team arrested Gabriel Esparza, a 20-year-old man and Whittier resident, in connection with the kidnapping and shooting of Vazquez. Mr Esparza was taken into custody at his workplace in the city of Lakewood and booked into the Whittier Police Department jail on charges of murder and kidnapping. He is being held without bail. During his arrest, officers recovered a weapon and Esparza’s White Toyota Tacoma truck – which are believed to have been used at the time of the shooting. “This relentless investigation and yesterday’s arrest were made possible by the dedication and commitment of our investigations division, with the assistance of the Riverside County Sheriff’s Department, Los Angeles County Sheriff’s Department, Downey Police Department, La Habra Police Department and the LADA Investigations Bureau Community Violence Reduction Team,” police said in a statement. The case will be presented to the Los Angeles County District Attorney’s office on Wednesday 23 August. Suspect pleads not guilty in first court appearance Gabriel Sean Esparza, the 20-year-old son of a Los Angeles County fire captain, has been charged with multiple felonies including murder, kidnapping and attempted rape of 19-year-old Andrea Vazquez. Mr Esparza entered a not-guilty plea when he made his first court appearance for the brutal slaying on Wednesday afternoon. Prosecutors have formally filed seven charges against the suspect, according to a criminal complaint submitted in Los Angeles Superior Court. These also include attempted murder, kidnapping to commit another crime, assault with intent to commit a felony, and two counts of attempted forcible rape. Tributes pour in Vasquez attended Fullerton College and was a fashion design student as well as an employee at a shopping mall in Cerritos. Ms Martinez told Fox News Digital before her body was found that the 19-year-old had also been working with her sister Edlyn, who is a lash artist. She described Vazquez as the “funniest person ever” and a “beautiful person” who was liked by everyone who met her. Read More Andrea Vazquez – latest: Gabriel Esparza arrested for murder after kidnapping teen on date with boyfriend Andrea Vazquez: California woman shot and kidnapped from boyfriend’s car found dead