In a podcast, Charli and Dixie D’Amelio revealed who spends the most time on social media between the two of them

History shows they are inappropriately targeted over actions in the Middle East, the foreign secretary says.

On the anniversary of Mahsa Amini’s death, President Joe Biden has announced that the U_S_ will impose more sanctions on Iranian people and firms, “targeting some of Iran’s most egregious human rights abusers.”

Jill Biden has represented her country at the Olympics, a king's coronation and a royal wedding

A treatment for acute migraines has been approved for NHS use for the first time, with experts saying the move could be a “step-change” for thousands of people who suffer from the condition. The National Institute for Health and Care Excellence (Nice) said its final draft guidance on Rimegepant “addresses the high unmet need for treatment options for acute migraine”. Rimegepant, also known as Vydura and made by Pfizer, will be available to adults who have tried at least two triptans – medication usually given to tackle headaches or migraines – but found they did not work well enough. It can also be administered to those who are not able to take triptans or have an intolerance, or patients who have tried nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol. Helen Knight, director of medicines evaluation at Nice, said: “Migraine is a condition described in comments to Nice from carers and people with migraine as an invisible disability that affects all aspects of life including work, education, finances, mental health, social activities and family. “Today’s final draft guidance addresses the high unmet need for treatment options for acute migraine, once again demonstrating our ability to ensure clinically and cost-effective medicines are available to those who need them as quickly as possible.” Rimegepant is taken as a wafer, which dissolves under the tongue and works by stopping the release of a protein around the brain called calcitonin gene-related peptide. In July, the medicine was recommended as an option for preventing episodic migraines in adults who have at least four and fewer than 15 attacks per month if “at least” three other treatments have not worked. This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment Helen Knight, Nice Under the latest guidance, it will also be used to relieve symptoms of a migraine, which can include pain, nausea and sensitivity to light, but also painless symptoms such as temporary visual disturbances known as “aura”, which Nice said “is not well managed with existing treatments”. The recommendation is expected to benefit about 13,000 people. Ms Knight added: “This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment.” Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health Robert Music, The Migraine Trust Robert Music, chief executive of The Migraine Trust, said the Nice guidance “provides people with migraine valuable options to help reduce the pain and length of a migraine attack”. “It brings new hope,” he added. “It will especially benefit those who have not found a treatment that works, those who get debilitating side effects – including medicine overuse headache – from them, and those with cardiovascular disease who cannot take existing treatments. “Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health.” Read More NHS winter resilience fund announced by Government NHS reliance on paper notes ‘stopping trusts from realising full potential’ Recession fears as UK economy shrinks by more than expected in shock decline Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

US Republicans launch impeachment inquiry hearings into Joe Biden on Thursday, escalating an eight-month corruption investigation that has failed to uncover evidence...

Provides an overview of Niger, including key dates and facts about this west African country.

Negotiators are nearing a possible deal, US media report, ahead of a holiday weekend.

X Here is a list of additional legal troubles facing former President Donald Trump, who wrote on social

'Today' show was the first to announce the good news to all Al Roker's fans

Apart from her performance, Mariah Carey will also be honored for her song, 'All I Want For Christmas Is You', during the 2023 Billboard Music Awards

Khloe Kardashian has officially changed her son Tatum’s last name, one year after his birth. A Los Angeles county judge granted the name change for the baby – who Kardashian shares with ex Tristan Thompson – on 31 August, according to documents obtained by US Weekly. In June, the publication had first reported that Tatum’s last name was initially listed as “Kardashian” on his birth certificate. Now, the 13-month old has been granted a new surname, which is the same as his father’s, officially decreeing him “Tatum Thompson”. Similar to law in other states, California law allows parents to pick if they want their child to have their father or mother’s last name. Parents can also do the combination of the two, and give the baby a surname with a hyphen in between the two last names. The law states that whatever last name is picked will be permanent, as a court order is required to change the name. In July 2022, the former couple welcomed their child, Tatum, together via surrogate. They also share a five-year-old daughter, True. The arrival of the pair’s second baby came months after they ended their on-and-off relationship, when Thompson confirmed he fathered a son with fitness instructor Maralee Nichols. In the most recent season of The Kardashians, the Good American founder has also spoken candidly about raising her son. During an episode of season three, which aired in June, she admitted to feeling less bonded to her son born via surrogacy than her daughter True, who she birthed herself. “With True, it took me a couple of days to be like, okay, this is my daughter,” Kardashian said. “With him, it’s taken me months. I love him and I love kids but, I still don’t have that complete bond.” Kardashian added that she sometimes felt “guilty” that she hadn’t bonded with her son in the same way as her daughter. “I’m like, why isn’t it the same? But I know it will be and I know, like, I don’t treat him differently. I just question myself sometimes,” she explained. Despite her challenges and feelings about her son, Kardashian also acknowledged that she was being hard on herself. “I wish I wasn’t so critical of myself because I’m very kind to everyone else,” Kardashian said in her confessional. “I’m just not very kind to myself.” “But being a mom is truly one of the most magical experiences ever,” she added. In July, Kardashian took to Instagram to share a series of photos of Tatum in honour of his first birthday. She also included a sweet tribute about her relationship with her son, in which she expressed how ​“God knew [her] heart needed” him when he was born. “I am so proud to be your mommy. So proud of the love and laughter we have in our house. So proud of your beautiful, gentle, loving, infectious spirit. You light up every single room. There’s no denying that everyone smiles when they look at you!” she wrote. “Especially True, she is so proud to call you hers.” Read More Khloe Kardashian denies disrespecting Halle Berry and says ‘don’t tear me apart’ amid Tristan Thompson reports Khloe Kardashian reveals ex Tristan Thompson and his brother moved in with her after their mother died Kylie Jenner addresses the ‘misconceptions’ she’s had plastic surgery Khloe Kardashian officially changes son Tatum’s last name Khloe Kardashian takes swipe at ‘hater’ for insulting sister Kim What is Merkel cell skin cancer? The signs and symptoms of the rare condition